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From WikiMesothelioma — Mesothelioma Knowledge Base


Mesothelioma is a rare and aggressive cancer that affects the protective lining of the lungs, abdomen, or heart. This guide provides comprehensive information about treatment options available in 2026.

Overview

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Mesothelioma treatment has advanced significantly in recent years. The primary treatment modalities include:

  • Surgery
  • Chemotherapy
  • Radiation therapy
  • Immunotherapy
  • Clinical trials

Treatment Options

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Surgery

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Surgical options depend on the location and stage of the disease. Common procedures include:

  • Pleurectomy/Decortication (P/D) - Removal of the pleural lining
  • Extrapleural Pneumonectomy (EPP) - Removal of entire lung and surrounding tissue
  • Cytoreduction surgery - For peritoneal mesothelioma

Chemotherapy

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Standard chemotherapy regimens typically combine:

  • Pemetrexed (Alimta)
  • Cisplatin or Carboplatin

These drugs work together to target rapidly dividing cancer cells.[1]

Immunotherapy

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Recent FDA approvals have expanded treatment options:

  • Nivolumab (Opdivo)
  • Ipilimumab (Yervoy)

These medications help the immune system recognize and attack cancer cells.

References

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  1. National Cancer Institute, 2025