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Mesothelioma is a rare and aggressive cancer that affects the protective lining of the lungs, abdomen, or heart. This guide provides comprehensive information about treatment options available in 2026.

Overview

Mesothelioma treatment has advanced significantly in recent years. The primary treatment modalities include:

• Surgery
• Chemotherapy
• Radiation therapy
• Immunotherapy
• Clinical trials

Treatment Options

Surgery

Surgical options depend on the location and stage of the disease. Common procedures include:

• Pleurectomy/Decortication (P/D) - Removal of the pleural lining
• Extrapleural Pneumonectomy (EPP) - Removal of entire lung and surrounding tissue
• Cytoreduction surgery - For peritoneal mesothelioma

Chemotherapy

Standard chemotherapy regimens typically combine:

• Pemetrexed (Alimta)
• Cisplatin or Carboplatin

These drugs work together to target rapidly dividing cancer cells.

Immunotherapy

Recent FDA approvals have expanded treatment options:

• Nivolumab (Opdivo)
• Ipilimumab (Yervoy)

These medications help the immune system recognize and attack cancer cells.