...ame="dandell_diagnosis" /> The '''MESOMARK assay''' — measuring '''soluble mesothelin-related peptides (SMRP)''' — is the only '''FDA-approved''' blood biomarker
* '''Soluble mesothelin 0.3 nM detection limit''' — SMRP levels correlate directly with tumor volum
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...0px; border-bottom:1px solid #dee2e6;" | '''15 months''' before diagnosis (mesothelin + calretinin)
| style="padding:10px; border-bottom:1px solid #dee2e6;" | '''0.99''' (mesothelin + fibulin-3 + HMGB1)
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39 KB (5,116 words) - 10:12, 6 April 2026
...ensive guide to CAR-T cell therapy for malignant mesothelioma. Learn about mesothelin-targeted CAR-T cells, MSKCC clinical trial results showing 72% response rat
...CAR-T cell therapy mesothelioma, chimeric antigen receptor T-cell therapy, mesothelin CAR-T, intrapleural CAR-T, MSKCC mesothelioma CAR-T, CAR-T clinical trials
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66 KB (8,673 words) - 02:53, 4 March 2026
...or treating fields (FDA-approved under Humanitarian Device Exemption), and mesothelin-targeted CAR-T cell therapy showing a '''72% response rate''' in early-phas
* '''CAR-T cell therapy shows early promise''' — mesothelin-targeted CAR-T cells delivered intrapleurally with pembrolizumab achieved a
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...vation:''' SMRP levels are typically elevated, facilitating use of soluble mesothelin-related peptide as a prognostic marker and treatment response monitor.<ref
* '''Poor Biomarker Utility:''' Mesothelin/SMRP levels are typically normal or low, limiting diagnostic biomarker util
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40 KB (5,072 words) - 20:56, 20 February 2026
| '''Mesothelin Biomarker Accuracy''' || 61% sensitivity, 87% specificity; FDA-approved dia
| '''Mesothelin (SMRP)''' || 61% || 87% || FDA-approved diagnostic marker; most validated |
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43 KB (5,354 words) - 03:51, 9 March 2026
...ed surveillance. The MESOMARK assay, which quantitatively measures soluble mesothelin-related peptides (SMRP) in serum, is the only FDA-cleared biomarker for mes
A large individual patient data meta-analysis found that serum mesothelin achieved a sensitivity of only 32% (95% CI: 26%–40%) at 95% specificity for
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This Phase I dose-escalation study evaluates anti-mesothelin TNaive/SCM hYP218 CAR T cells, designed for enhanced tumor infiltration and
* '''Innovation:''' Targets membrane-proximal epitope of mesothelin, showing 2-4 fold better tumor killing than membrane-distal approaches in p
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39 KB (4,791 words) - 23:07, 10 March 2026
* Pioneer of mesothelin-targeted CAR T-cell therapy for mesothelioma
The most significant innovation at MSK is the development of mesothelin-targeted CAR T-cell therapy. This approach:
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29 KB (3,631 words) - 20:56, 20 February 2026
...l therapy for mesothelioma and solid tumors. His phase I trial of regional mesothelin-targeted CAR T-cell therapy combined with pembrolizumab achieved a 72 perce
...ies exploiting mesothelin as a therapeutic target. He has brought multiple mesothelin-directed agents to clinic, including SS1P and LMB-100 (immunotoxins), Amatu
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63 KB (8,220 words) - 22:37, 8 March 2026
...AUC 0.99 in training set but 0.87 on independent validation; comparable to mesothelin; Pass et al. 2012, NEJM<ref name="pmc_fibulin" />
=== MESOMARK (Soluble Mesothelin-Related Peptides / SMRP) ===
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...py modifies patients' own T-cells to recognize and attack cells expressing mesothelin, a protein highly overexpressed in mesothelioma. Several constructs are in
...-T:''' Memorial Sloan Kettering launched a phase I trial in 2025 combining mesothelin-targeted CAR-T with an anti-PD-1 component
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38 KB (4,755 words) - 03:42, 9 March 2026
...dified cell therapies such as [[CAR-T_Cell_Therapy|CAR-T cells]] targeting mesothelin — represents a closely related but distinct modality.<ref name="pmclung" />
...humoral responses to known tumor antigens such as SV40 large T antigen and mesothelin. Four of 10 patients showed meaningful clinical responses defined as diseas
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67 KB (8,763 words) - 09:18, 6 April 2026
* '''Mesothelin (SMRP):''' FDA-approved biomarker for mesothelioma diagnosis and monitoring
...and specificity 82-89%. Initial reports suggested superior performance to mesothelin, but subsequent validation studies found lower accuracy. Fibulin-3 levels i
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...ved an AUC of 0.95 with 93.2% sensitivity, and a three-marker combination (mesothelin + fibulin-3 + HMGB1) reached AUC 0.99 with 96% sensitivity.<ref name="meson
'''CAR-T cell therapy''' targeting mesothelin remains in Phase 1/2. Memorial Sloan Kettering's predecessor trial showed a
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62 KB (7,831 words) - 01:11, 6 April 2026
...kers for mesothelioma include calretinin, WT1, cytokeratin 5/6, D2-40, and mesothelin, while negative results for markers like TTF-1, CEA, and MOC-31 help exclud
* [[#Mesothelin|Mesothelin]]
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216 KB (26,444 words) - 23:30, 23 January 2026
| style="padding:10px; border-bottom:1px solid #dee2e6;" | Mesothelin-targeted CAR-T cells delivered intrapleurally with pembrolizumab achieved O
Soluble mesothelin-related peptides ('''SMRP/MESOMARK''') remain the only FDA-approved serum b
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59 KB (7,425 words) - 01:11, 6 April 2026
...clinical trial programs in the world. MSK's most celebrated trial involves mesothelin-targeted CAR T-cell therapy (NCT04577326), a phase I dose-escalation study
...altrials-cart">[https://clinicaltrials.gov/study/NCT04577326 NCT04577326 — Mesothelin-targeted CAR T-cell Therapy], ClinicalTrials.gov, National Library of Medic
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54 KB (6,938 words) - 09:55, 6 April 2026
* Mesothelin (SMRP)
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A multi-site trial evaluating the safety and efficacy of mesothelin-targeting logic-gated CAR T cells in participants with solid tumors. This n
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26 KB (3,157 words) - 20:56, 20 February 2026
