...oma Diagnostic Technology 2025-2026: TNM 9th Edition, AI Pathology, Liquid Biopsy
...M 9th edition pleural thickness staging, BAP1+MTAP IHC, cfMeDIP-seq liquid biopsy, AI pathology, ASCO 2025.
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* Liquid biopsy and ctDNA monitoring
...ized medicine, adding capabilities like whole-genome sequencing and liquid biopsy monitoring that did not exist during Sugarbaker's tenure.
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* '''Liquid biopsy vs. tissue biopsy''' — cell-free DNA methylation profiling achieved 91% accuracy as a non-inv
| style="padding:10px; border:1px solid #dee2e6;" | '''cfMeDIP-seq Liquid Biopsy'''
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...ile organic compound breath analysis, and chromosomal rearrangement liquid biopsy, may enable earlier detection in high-risk asbestos-exposed populations.<re
...sed patient, should trigger immediate referral for specialized imaging and biopsy. Pleural effusion is also an independent prognostic factor predicting worse
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...mpared to 73.8% for lung cancer and 82.0% for breast cancer, making tissue biopsy frequently necessary<ref name="martinez" />
* '''Thoracoscopic biopsy vs cytology diagnostic accuracy''' — thoracoscopy achieves 91.5% sensitivit
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'''Liquid Biopsy (ctDNA):''' A landmark 2025 Nature Medicine study validated circulating tum
'''Methylation-Based Classification:''' cfMeDIP-seq liquid biopsy can distinguish epithelioid from sarcomatoid histology with 98% accuracy an
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| style="padding:10px;" | '''Liquid Biopsy'''
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...) for pleural cases, laparoscopy for peritoneal cases, or CT-guided needle biopsy. Fluid cytology from pleural or peritoneal effusions may suggest mesothelio
...signation in April 2025 for multi-tissue cancer detection.<ref name="dx-ai-biopsy" />
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=== Tissue Biopsy ===
...T-guided core needle biopsy''' for lesions accessible percutaneously. VATS biopsy is generally preferred because it provides larger tissue samples, allows as
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# '''Pathology or biopsy report''' confirming mesothelioma diagnosis
In the landmark '''Air & Liquid Systems Corp. v. DeVries''' (2019), the U.S. Supreme Court ruled 6-3 that m
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'''Liquid Biopsy Breakthrough:''' Johns Hopkins' Phase 2 trial demonstrated that patients wi
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