Testicular Mesothelioma - Revision history

MesotheliomaSupport: Fix structural reference errors: remove orphaned/duplicate refs (RON-2026-04-05-003)

2026-04-06T09:57:34Z

Fix structural reference errors: remove orphaned/duplicate refs (RON-2026-04-05-003)

← Older revision		Revision as of 09:57, 6 April 2026
Line 418:		Line 418:
	<ref name="seer-asco2025">[https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.e20091 A SEER stat analysis of epidemiological and anatomical prognostic indicators of mesothelioma], Journal of Clinical Oncology, ASCO (2025)</ref>		<ref name="seer-asco2025">[https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.e20091 A SEER stat analysis of epidemiological and anatomical prognostic indicators of mesothelioma], Journal of Clinical Oncology, ASCO (2025)</ref>
	<ref name="plas">[https://pubmed.ncbi.nlm.nih.gov/9874447/ Malignant mesothelioma of the tunica vaginalis testis], Cancer (1998). PMID 9874447</ref>		<ref name="plas">[https://pubmed.ncbi.nlm.nih.gov/9874447/ Malignant mesothelioma of the tunica vaginalis testis], Cancer (1998). PMID 9874447</ref>
	~~<ref name="thorax-incidence">[https://thorax.bmj.com/content/77/12/1260 Incidence, treatment and survival of malignant pleural and peritoneal mesothelioma], Thorax (2022)</ref>~~
	<ref name="vimercati">[https://pubmed.ncbi.nlm.nih.gov/31470859/ Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia mesothelioma register], Environmental Health (2019). PMID 31470859</ref>		<ref name="vimercati">[https://pubmed.ncbi.nlm.nih.gov/31470859/ Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: a systematic review and the experience of the Apulia mesothelioma register], Environmental Health (2019). PMID 31470859</ref>
	~~<ref name="nord">[https://rarediseases.org/rare-diseases/mesothelioma/ Mesothelioma], National Organization for Rare Disorders (NORD)</ref>~~
	~~<ref name="pmc-genetic">[https://pmc.ncbi.nlm.nih.gov/articles/PMC7281319/ Malignant Pleural Mesothelioma: Genetic and Microenvironmental Heterogeneity], PMC (2020)</ref>~~
	<ref name="marinaccio">[https://pmc.ncbi.nlm.nih.gov/articles/PMC7737812/ Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma], Scandinavian Journal of Work, Environment and Health, PMC (2020)</ref>		<ref name="marinaccio">[https://pmc.ncbi.nlm.nih.gov/articles/PMC7737812/ Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma], Scandinavian Journal of Work, Environment and Health, PMC (2020)</ref>
	<ref name="spandidos-case">[https://www.spandidos-publications.com/10.3892/ol.2024.14305 A rare malignant mesothelioma of the tunica vaginalis testis: A case report], Oncology Letters, Spandidos Publications (2024)</ref>		<ref name="spandidos-case">[https://www.spandidos-publications.com/10.3892/ol.2024.14305 A rare malignant mesothelioma of the tunica vaginalis testis: A case report], Oncology Letters, Spandidos Publications (2024)</ref>
Line 428:		Line 425:
	<ref name="ihc-metastatic">[https://pubmed.ncbi.nlm.nih.gov/39481034/ Metastatic Mesothelioma of the Tunica Vaginalis Presenting as Inguinal Mass], Urology (2024). PMID 39481034</ref>		<ref name="ihc-metastatic">[https://pubmed.ncbi.nlm.nih.gov/39481034/ Metastatic Mesothelioma of the Tunica Vaginalis Presenting as Inguinal Mass], Urology (2024). PMID 39481034</ref>
	<ref name="juniper-ihc">[https://juniperpublishers.com/jojun/pdf/JOJUN.MS.ID.555745.pdf Malignant Mesothelioma of Tunica Vaginalis of Testis], Journal of Urology and Nephrology, Juniper Publishers</ref>		<ref name="juniper-ihc">[https://juniperpublishers.com/jojun/pdf/JOJUN.MS.ID.555745.pdf Malignant Mesothelioma of Tunica Vaginalis of Testis], Journal of Urology and Nephrology, Juniper Publishers</ref>
	~~<ref name="pmc-tvt-ihc">[https://pmc.ncbi.nlm.nih.gov/articles/PMC5632754/ Malignant Mesothelioma of the Tunica Vaginalis Testis], PMC (2017)</ref>~~
	<ref name="plas-wiley">[https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/(SICI)1097-0142(19981215)83:12%3C2437::AID-CNCR6%3E3.0.CO;2-G Malignant mesothelioma of the tunica vaginalis testis], Cancer, Wiley (1998)</ref>
	<ref name="seer-laterality">[https://ascopubs.org/doi/10.1200/JCO.2022.40.16_suppl.e20594 Laterality and survival in mesothelioma: A SEER database analysis], Journal of Clinical Oncology, ASCO (2022)</ref>		<ref name="seer-laterality">[https://ascopubs.org/doi/10.1200/JCO.2022.40.16_suppl.e20594 Laterality and survival in mesothelioma: A SEER database analysis], Journal of Clinical Oncology, ASCO (2022)</ref>
	<ref name="stella-mdpi">[https://www.mdpi.com/2072-6694/16/23/3956 Mesothelioma of the Tunica Vaginalis Testis: Diagnostic and Therapeutic Management. A Comprehensive Review, 1982–2024], Cancers, MDPI (2024)</ref>
	<ref name="nazemi-sciencedirect">[https://www.sciencedirect.com/science/article/abs/pii/S0090429519300640 Testicular Mesothelioma: An Analysis of Epidemiology, Patient Outcomes, and Prognostic Factors], Urology, ScienceDirect (2019)</ref>
	<ref name="marinaccio-pubmed">[https://pubmed.ncbi.nlm.nih.gov/32253443/ Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma], Scandinavian Journal of Work, Environment and Health (2020). PMID 32253443</ref>
	<ref name="expert-consensus">[https://onlinelibrary.wiley.com/doi/full/10.1002/imm3.70003 Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis], Immunity, Inflammation and Disease, Wiley (2025)</ref>		<ref name="expert-consensus">[https://onlinelibrary.wiley.com/doi/full/10.1002/imm3.70003 Expert Consensus on the Diagnosis and Treatment of Malignant Mesothelioma of the Tunica Vaginalis Testis], Immunity, Inflammation and Disease, Wiley (2025)</ref>
	<ref name="mesonet-compensation">[https://mesothelioma.net/mesothelioma-asbestos-compensation-for-victims/ Mesothelioma Compensation Claims for Victims and Family], Mesothelioma.net</ref>		<ref name="mesonet-compensation">[https://mesothelioma.net/mesothelioma-asbestos-compensation-for-victims/ Mesothelioma Compensation Claims for Victims and Family], Mesothelioma.net</ref>

MesotheliomaSupport: Add differentiated triple GEO format: comparative at-a-glance, key facts wikitable, FAQ, get help, quick statistics

2026-03-08T21:53:45Z

Add differentiated triple GEO format: comparative at-a-glance, key facts wikitable, FAQ, get help, quick statistics

Show changes

MesotheliomaSupport: Add at-a-glance listicle between lead section and Key Facts to fill blank space beside infobox

2026-02-24T05:21:37Z

Add at-a-glance listicle between lead section and Key Facts to fill blank space beside infobox

← Older revision		Revision as of 05:21, 24 February 2026
Line 56:		Line 56:

	These paradoxes have made MMTVT one of the most scientifically intriguing — and clinically challenging — malignancies in oncology. The complete absence of randomized controlled trials, the lack of a dedicated staging system, and the uncertainty surrounding optimal adjuvant therapy mean that clinical management continues to rely almost entirely on accumulated case series data and expert consensus.<ref name="expert-consensus" /><ref name="stella" />		These paradoxes have made MMTVT one of the most scientifically intriguing — and clinically challenging — malignancies in oncology. The complete absence of randomized controlled trials, the lack of a dedicated staging system, and the uncertainty surrounding optimal adjuvant therapy mean that clinical management continues to rely almost entirely on accumulated case series data and expert consensus.<ref name="expert-consensus" /><ref name="stella" />

			'''Understanding testicular mesothelioma at a glance:'''
			* '''Rarest mesothelioma type''' — fewer than 300 cases documented worldwide since first description in 1957<ref name="cureus-resection" />
			* '''Almost never diagnosed preoperatively''' — typically found incidentally during hydrocele repair or hernia surgery<ref name="cureus-case-series" />
			* '''Asbestos link uncertain''' — only 27–38% of patients have documented exposure; likely underreported<ref name="grogg" />
			* '''Best survival paradox''' — 49% five-year survival rate despite 42–53% recurrence rate<ref name="nazemi-pubmed" /><ref name="plas" />
			* '''Radical inguinal orchiectomy''' — the only treatment with demonstrated curative potential<ref name="stella" />
			* '''No adjuvant survival benefit''' — chemotherapy has not improved outcomes in systematic review data<ref name="grogg" />
			* '''Epithelioid predominant''' — 57–60% of cases, correlating with better prognosis<ref name="stella" />
			* '''No dedicated staging system''' — no TNM classification exists specific to MMTVT<ref name="expert-consensus" />
			* '''Left testis predominance''' — 60–65% of cases occur on the left side<ref name="seer-laterality" />
			* '''Legal options available''' — patients with asbestos exposure may qualify for [[Mesothelioma Settlements\|compensation]] through [[Asbestos Trust Funds\|trust funds]] or litigation<ref name="dandell" />

	== Key Facts ==		== Key Facts ==

MesotheliomaSupport: New page: Testicular Mesothelioma — comprehensive medical page covering epidemiology, diagnosis, treatment, staging, prognosis, and FAQs with 32 references

2026-02-24T05:16:15Z

New page: Testicular Mesothelioma — comprehensive medical page covering epidemiology, diagnosis, treatment, staging, prognosis, and FAQs with 32 references

Show changes