Editing Survival Statistics (section)

== What New Treatments Are Improving Survival in 2025? ==

Several breakthrough therapies are demonstrating remarkable efficacy and may further improve survival outcomes in the coming years.<ref>[https://mesotheliomaattorney.com/mesothelioma/treatment/new/ New Mesothelioma Treatments], Mesothelioma Attorney</ref>

'''VT3989 (TEAD Inhibitor)''' received FDA Fast Track Designation in October 2025 after demonstrating exceptional results in heavily pretreated patients.<ref>[https://dandell.com/mesothelioma/ Asbestos & Mesothelioma Lawyers], Danziger & De Llano</ref> This first-in-class therapy achieved 86% disease control rate and 32% objective response rate, with median progression-free survival of approximately 10 months—more than double the 15-week benchmark for salvage chemotherapy. A Phase 3 registrational trial is planned for early 2026.

'''CAR-T Cell Therapy''' continues showing remarkable durability. Memorial Sloan Kettering's mesothelin-targeted CAR-T program has demonstrated responses lasting beyond 5 years in early patients, with one patient first treated in 2019 remaining disease-controlled as of late 2024.<ref>[https://mesothelioma.net/clinical-trials-for-mesothelioma-treatment-what-to-expect/ Clinical Trials for Mesothelioma Treatment], Mesothelioma.net</ref> Chinese trials reported 100% objective response rate at higher doses, including durable complete responses.

'''BNT327/PM8002 (Bispecific Antibody)''' demonstrated 51.6% confirmed objective response rate and 90.3% disease control rate in Phase 2 trials, representing one of the highest response rates seen in unresectable mesothelioma.<ref>[https://www.mesotheliomalawyercenter.org/entity/mesothelioma/ Mesothelioma], Mesothelioma Lawyer Center</ref>

'''ATOMIC-meso (ADI-PEG20)''' achieved its primary endpoint for non-epithelioid mesothelioma, demonstrating a 29% reduction in death risk and quadrupling 3-year survival compared to placebo plus chemotherapy.<ref>[https://mesothelioma.net/treatment-for-mesothelioma/ Mesothelioma Treatment], Mesothelioma.net</ref>