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== What Are the Four Types of Mesothelioma? == {| class="wikitable" style="width:100%; margin:1em 0; border-collapse:collapse;" |- ! style="background:#1a5276; color:white; padding:12px; text-align:left; width:20%;" | Type ! style="background:#1a5276; color:white; padding:12px; text-align:left; width:15%;" | Percentage ! style="background:#1a5276; color:white; padding:12px; text-align:left; width:25%;" | Location ! style="background:#1a5276; color:white; padding:12px; text-align:left; width:40%;" | Treatment Outlook |- | style="padding:12px; font-weight:bold; background:#e8f4f8;" | Pleural | style="padding:12px; background:#e8f4f8;" | 75-80% | style="padding:12px; background:#e8f4f8;" | Lung lining (pleura) | style="padding:12px; background:#e8f4f8;" | Most established surgical options; median survival 38+ months at top centers |- | style="padding:12px; font-weight:bold;" | Peritoneal | style="padding:12px;" | 20-24% | style="padding:12px;" | Abdominal lining (peritoneum) | style="padding:12px;" | Best prognosis with HIPEC surgery; 3-5 year median survival possible |- | style="padding:12px; font-weight:bold; background:#e8f4f8;" | Pericardial | style="padding:12px; background:#e8f4f8;" | <1% | style="padding:12px; background:#e8f4f8;" | Heart lining (pericardium) | style="padding:12px; background:#e8f4f8;" | Limited options due to location; 6-10 month median survival |- | style="padding:12px; font-weight:bold;" | Testicular | style="padding:12px;" | <1% | style="padding:12px;" | Tunica vaginalis (testes) | style="padding:12px;" | Rarest form; often better prognosis when caught early |} === Pleural Mesothelioma: The Most Common Diagnosis === Pleural mesothelioma develops in the pleura, the two-layer membrane surrounding the lungs, and represents approximately 75-80% of all mesothelioma diagnoses. The pleura consists of a visceral layer directly covering the lung surface and a parietal layer lining the chest cavity, with a small amount of lubricating fluid between them enabling smooth breathing movements ([https://www.mesotheliomalawyercenter.org/asbestos/diseases/pleural-effusion/ Pleural Effusion Information]). Common symptoms of pleural mesothelioma include persistent shortness of breath, chest pain that worsens with deep breathing, unexplained weight loss, and chronic dry cough. These symptoms develop as tumors thicken the pleural membranes and fluid accumulates in the chest cavity, compressing lung tissue. Diagnosis typically involves imaging scans followed by a tissue biopsy to confirm the presence of malignant mesothelioma cells. From a treatment perspective, pleural mesothelioma offers the most established surgical options, including pleurectomy/decortication (P/D) and extrapleural pneumonectomy (EPP). Modern P/D techniques at specialized centers have demonstrated median survival of 38.1 months for appropriate surgical candidates, compared to historical averages of 12-14 months ([https://mesotheliomaattorney.com/mesothelioma/types/pleural/ Pleural Mesothelioma Treatment]). === Peritoneal Mesothelioma: The Second Most Common Type === Peritoneal mesothelioma affects the peritoneum, the membrane lining the abdominal cavity, and accounts for approximately 20-24% of mesothelioma cases ([https://mesotheliomaattorney.com/mesothelioma/types/peritoneal/ Peritoneal Mesothelioma Guide]). This type develops when swallowed asbestos fibers become embedded in abdominal tissue, causing cellular damage over decades that eventually results in cancerous growth. Symptoms often include abdominal pain and swelling, changes in bowel habits, unexplained weight loss, and fluid accumulation in the abdomen (ascites). Because these symptoms mimic common digestive conditions, peritoneal mesothelioma is frequently misdiagnosed initially, resulting in delayed treatment. {| style="width:100%; background:#d4edda; border:1px solid #28a745; border-left:5px solid #28a745; border-radius:4px; margin:1em 0;" |- | style="padding:15px; color:#155724;" | '''✓ Good News:''' Peritoneal mesothelioma often carries a more favorable prognosis than pleural cases when treated with modern approaches. Cytoreductive surgery combined with HIPEC (Heated Intraperitoneal Chemotherapy) has transformed outcomes, with specialized centers reporting median survival of 3-5 years and some patients achieving 70% five-year survival rates ([https://mesothelioma.net/treatment-for-mesothelioma/ Mesothelioma Treatment Options]). |} === Pericardial Mesothelioma: Rare Heart Lining Cancer === Pericardial mesothelioma develops in the pericardium, the protective sac surrounding the heart, and represents less than 1% of all mesothelioma cases. This extremely rare form presents unique challenges because symptoms including chest pain, irregular heartbeat, difficulty breathing, and fatigue closely mimic common cardiac conditions. The rarity of pericardial mesothelioma often delays accurate diagnosis, with some cases not identified until autopsy. Treatment options are limited due to the tumor's proximity to the heart, though palliative procedures like pericardiocentesis (draining excess fluid) can provide symptomatic relief. Median survival typically ranges from 6-10 months from diagnosis ([https://mesothelioma.net/mesothelioma-prognosis/ Mesothelioma Prognosis]). From a legal perspective, pericardial mesothelioma cases often receive higher compensation due to the aggressive nature of the disease and limited treatment options. Virtually all pericardial mesothelioma cases are linked to asbestos exposure, and courts and trust funds generally recognize the devastating nature of this diagnosis ([https://dandell.com/mesothelioma/mesothelioma-case-worth/ Case Value Information]). === Testicular Mesothelioma: The Rarest Form === Testicular mesothelioma, developing in the tunica vaginalis membrane covering the testes, is the rarest form with fewer than 100 cases documented in medical literature. This type typically presents as a painless mass or swelling in the scrotum and is often initially mistaken for more common conditions like hydrocele or hernia. Despite its extreme rarity, testicular mesothelioma sometimes offers a more favorable prognosis than other types, particularly when diagnosed early. Treatment usually involves surgical removal of the affected testicle (radical orchiectomy) followed by chemotherapy or radiation, with some patients achieving long-term survival or cure.
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