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== How Does Mesothelioma Type Affect Survival? == The location where mesothelioma develops dramatically influences survival outcomes.<ref>[https://dandell.com/mesothelioma/mesothelioma-diagnosis/pleural-vs-peritoneal-mesothelioma-differences/ Pleural vs Peritoneal Mesothelioma], Danziger & De Llano</ref> Peritoneal mesothelioma, arising in the abdominal lining, maintains substantially better prognosis than pleural mesothelioma affecting the lung lining. '''Peritoneal Mesothelioma''' demonstrates 65% 5-year survival compared to just 12% for pleural disease.<ref>[https://dandell.com/mesothelioma-lawyer/texas/houston/ Houston Mesothelioma Lawyer], Danziger & De Llano</ref> One-year survival rates are 92% for peritoneal versus 73% for pleural patients. This dramatic difference reflects both the disease biology and availability of highly effective cytoreductive surgery with heated intraperitoneal chemotherapy (HIPEC).<ref>[https://www.mesotheliomalawyercenter.org/peritoneal-mesothelioma-cancer/ Peritoneal Mesothelioma Cancer], Mesothelioma Lawyer Center</ref> '''Pleural Mesothelioma''' represents approximately 80% of all cases and carries median survival of 12-21 months depending on stage, histology, and treatment approach.<ref>[https://mesotheliomaattorney.com/mesothelioma/types/pleural/ Pleural Mesothelioma], Mesothelioma Attorney</ref> However, patients treated at specialized mesothelioma centers achieve significantly better outcomes, with some programs reporting survival rates 2.5 times national averages. '''Pericardial and Testicular Mesothelioma''' are rare variants representing less than 3% of cases combined. Testicular mesothelioma paradoxically shows the best prognosis among all types when treated surgically, while pericardial mesothelioma carries poor prognosis due to its location around the heart.<ref>[https://mesothelioma.net/pericardial-mesothelioma/ Pericardial Mesothelioma], Mesothelioma.net</ref>
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