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=== Heated Chemotherapy Integration (HIPEC/HITHOC) === Specialized centers have refined heated intraoperative chemotherapy approaches that deliver concentrated drug therapy directly to the surgical site: '''MD Anderson Cancer Center''': Pioneers in heated chemotherapy for peritoneal mesothelioma, achieving response rates exceeding 40% when combined with optimal cytoreductive surgery.<ref>[https://mesotheliomaattorney.com/mesothelioma/types/peritoneal/ Peritoneal Mesothelioma Guide], MesotheliomaAttorney.com</ref> '''University of Chicago''': Under Dr. Hedy Lee Kindler's leadership, the program integrates HIPEC with immunotherapy for patients with abdominal mesothelioma, demonstrating '''3-5 years median survival''' with complete cytoreduction. '''AdventHealth Cancer Institute''' (Orlando): Dr. Marcelo DaSilva, trained under Dr. Sugarbaker at Brigham and Women's, leads one of the Southeast's premier programs for heated chemotherapy approaches using robotic surgical platforms. ----
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