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=== ISM6331 — First AI-Designed Drug for Mesothelioma (NCT06566079) === This pan-TEAD inhibitor was designed using Insilico Medicine's Chemistry42 AI platform, representing the first AI-designed drug to enter clinical testing for mesothelioma.<ref>[https://www.mesotheliomalawyercenter.org/mesothelioma/treatment/ Mesothelioma Treatment Options], Mesothelioma Lawyer Center</ref> '''Development Timeline:''' * '''September 2020:''' AI platform launched * '''June 2023:''' Recommended for preclinical studies * '''April 2024:''' AACR presentation showing broad cancer-killing effects * '''June 2024:''' FDA Orphan Drug Designation granted * '''August 2024:''' IND clearance received * '''January 22, 2025:''' First patient dosed in China * '''2026:''' US enrollment expected '''Mechanism:''' Pan-TEAD inhibitor blocking the palmitoylation site, disrupting YAP/TAZ-TEAD transcriptional activity
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